ABSTRACT
OBJECTIVE: Many changes in mucosal morphology are observed following ileal pouch construction, including colonic metaplasia and dysplasia. Additionally, one rare but potential complication is the development of adenocarcinoma of the reservoir. The aim of this study was to evaluate the most frequently observed histopathological changes in ileal pouches and to correlate these changes with potential risk factors for complications. METHODS: A total of 41 patients were enrolled in the study and divided into the following three groups: a non-pouchitis group (group 1) (n = 20; 8 males; mean age: 47.5 years) demonstrating optimal outcome; a pouchitis without antibiotics group (group 2) (n = 14; 4 males; mean age: 47 years), containing individuals with pouchitis who did not receive treatment with antibiotics; and a pouchitis plus antibiotics group (group 3) (n = 7; 3 males; mean age: 41 years), containing those patients with pouchitis who were administered antibiotics. Ileal pouch endoscopy was performed, and tissue biopsy samples were collected for histopathological analysis. RESULTS: Colonic metaplasia was found in 15 (36.6%) of the 41 patients evaluated; of these, five (25%) were from group 1, eight (57.1%) were from group 2, and two (28.6%) were from group 3. However, no correlation was established between the presence of metaplasia and pouchitis (p = 0.17). and no differences in mucosal atrophy or the degree of chronic or acute inflammation were observed between groups 1, 2, and 3 (p>0.45). Moreover, no dysplasia or neoplastic changes were detected. However, the degree of mucosal atrophy correlated well with the time of postoperative follow-up (p = 0.05). CONCLUSIONS: The degree of mucosal atrophy, the presence of colonic metaplasia, and the degree of acute or chronic inflammation do not appear to constitute risk factors for the development of pouchitis. Moreover, we observed that longer postoperative follow-up times were associated with greater degrees of mucosal atrophy.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Colitis, Ulcerative/surgery , Colonic Pouches/pathology , Pouchitis/etiology , Biopsy , Colitis, Ulcerative/pathology , Colon/pathology , Colonic Pouches/adverse effects , Intestinal Mucosa/pathology , Metaplasia , Pouchitis/pathology , Risk Factors , Severity of Illness IndexABSTRACT
A insuficiência renal aguda (IRA) devido à toxicidade por contrastes tem incidência em torno de 10 a 15. O contraste pode induzir a dois tipos de lesão renal, a necrose tubular aguda (NTA) e a nefrite túbulo-intersticial (NTIA).A necrose tubular aguda provoca lesão nas células epiteliais dos túbulos renais, diminui o fluxo urinário acentuadamente. Observa-se na urina tipo I cilindros granulosos, eritrócitos e células inflamatórias. A nefrite túbulo-intersticial fármaco-induzida é uma reação de hipersensibilidade não relacionada à dose, podendo ocorrer na ausência de qualquer manifestação sistêmica de hipersensibilidade.Nesse trabalho relataremos um caso clínico, no qual se observa um dos tipos de lesão renal induzida por contraste e salientamos que somente a prevenção através da hidratação prévia e após o uso do contraste tem se mostrado efetiva no tratamento da nefropatia induzida por este.(au)